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        1. 當前位置 首頁 科研隊伍

          中國科學院感染與免疫重點實驗室

          李新建  博士 研究員 博士生導師  

          中科院生物物理所,中科院感染與免疫重點實驗室,研究組長

          研究方向:腫瘤進展與天然免疫反應過程中的代謝重編程

          電子郵件:lixinjian@ibp.ac.cn

          電       話:010-64888557

          通訊地址:北京市朝陽區大屯路15號(100101)

          英文版個人網頁:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.salesdujour.com/sourcedb_ibp_cas/cn/ibpexport/EN_xsszmL/202005/t20200519_5582999.json

           

          簡       歷:

            2000 - 2004 華南農業大學,學士

            2004 - 2007 華南理工大學,碩士

            2008 - 2009 新加坡國立癌癥研究中心,聯合培養博士生

            2007 - 2011 中山大學,博士

            2011 - 2016 美國MD安德森癌癥中心,博士后

            2016 - 2019 美國MD安德森癌癥中心,講師

            2019 - 至今 中國科學院生物物理研究所,研究員

          獲獎及榮譽:

            2018 美中抗癌協會和美國亞洲癌癥研究基金會(USCACA-AFCR)獎學金

            2016 MD安德森癌癥中心Caroline Ross Endowed Fellowship

            2016 MD安德森癌癥中心The Harold C. and Mary L. Daily Endowment Fund Fellowship

            2015 MD安德森癌癥中心The Anne Eastland Spears Fellowship

            2013 MD安德森癌癥中心Odyssey Fellowship

          社會任職:

           

          研究方向:

            1. 揭示癌基因驅動的惡性腫瘤的代謝弱點。

            2. 鑒定具有免疫調節功能的代謝酶以及代謝產物。

          承擔項目情況:

           

          代表論著:

          (# First author, * corresponding author)

          1. Zhang ZX#, Li X#, Yang F#, Chen C#, Liu P, Ren Y, Sun PK, Wang ZX, You YP, Zeng YX, Li XJ*. DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis. Nature Communications 2021; 12(1): 5872

          2. Li XJ#*, Qian X#, Wang B, Xia Y, Zheng YH, Du LY, Xu DQ, Xing DM, DePinho RA, and Lu Z*. Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth. Nature Cell Biology 2020; 22 (3): 282-288 (Highlighted News & Views of Nature Cell Biology)

          3. Qian X#*, Li XJ#, Shi ZM, Bai XM, Xia Y, Zheng YH, Xu DQ, Chen F, You YP, Fang J, Hu ZB, Zhou Q, Lu Z*. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Molecular Cell 2019; 76(6): 885-895

          4. Qian X#*, Li XJ#, Shi ZM, Xia Y, Cai QS, Xu DQ, Tan L, Du LY, Zheng YH, Zhao D, Zhang CB, Lorenzi PL, You YP, Jiang BH, Jiang T, Li HT, Lu Z*. PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1. Molecular Cell 2019; 76(3): 516-527

          5. Li XJ#, Qian X#, Jiang HF, Xia Y, Zheng YH, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z*. Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication. Molecular Cell 2018; 72(4): 650-660

          6. Li XJ#, Egervari G#, Wang YG, Berger SL*, and Lu Z*. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nature Reviews Molecular Cell Biology 2018; 19(9): 563-578 (Cover story)  

          7. Qian X#, Li XJ#, Tan L, Lee JH, Xia Y, Cai QS, Zheng YH, Wang HX, Lorenzi PL, and Lu Z*. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discovery 2018; 8 (1): 94-107  

          8. Li XJ, Yu W, Qian X, Xia Y, Zheng YH, Lee JH, Li W, Lyu JX, Rao G, Zhang XC, Qian CN, Rozen SG, Jiang T, and Lu Z*. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy. Molecular Cell 2017; 66 (5): 684-697 (Research Highlight of Nature Reviews Molecular Cell Biology)  

          9. Li XJ, Qian X, Peng LX, Jiang YH, Hawke D, Zheng YH, Xia Y, Lee JH, Cote G, Wang HX, Wang LW, Qian CN, and Lu Z*. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology 2016; 18 (5): 561-571(Research Highlight of Science Signaling)  

          10. Li XJ, Jiang YH, Meisenhelder J, Yang WW, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang LW, and Lu Z*. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Molecular Cell 2016; 61 (5): 705-719  

          11. Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ,Zeng MS, Kang TB, Zeng YX, Teh BT, Qian CN*. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis 2012; 33 (7): 1302-1309 

          12. Li XJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ, Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN*. Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Research 2011;71 (8):3162-3172

           

          (資料來源:李新建研究員,2021-12-03)

           

          公交上拨开少妇内裤挺进去

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