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        1. 當前位置 首頁 科研隊伍

          中科院青促會會員

          丁璟珒  博士 研究員  

          中國科學院青年創新促進會會員
          國家“優秀青年基金”獲得者
          中科院生物物理所,生物大分子國家重點實驗室,研究組長

          研究方向:病原菌感染和宿主天然免疫防御的分子機理

          電子郵件:jding@ibp.ac.cn

          電       話:010-64888548

          通訊地址:北京市朝陽區大屯路15號(100101)

          英文版個人網頁:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.salesdujour.com/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582902.json

           

          簡       歷:

            1999.09 - 2003.07  武漢大學生命科學學院,理學學士

            2003.09 - 2008.07  中國科學院生物物理研究所,理學博士

            2008.10 - 2010.11  中國科學院生物物理研究所,博士后

            2010.11 - 2011.12  中國科學院生物物理研究所,助理研究員

            2012.01 - 2016.12  中國科學院生物物理研究所,副研究員

            2017.01 - 2017.12  中國科學院生物物理研究所,項目研究員

            2013.04 - 2017.12  北京生命科學研究所,訪問學者

            2018.01 - 至今       中國科學院生物物理研究所,研究員

          獲獎及榮譽:

           

          社會任職:

           

          研究方向:

            病原細菌的感染是人類生命活動的重要威脅,利用獨特的效應蛋白破壞機體的正常信號轉導或表達專門的耐藥基因拮抗抗菌藥物的殺滅,是許多病原菌感染致病的關鍵分子機制;天然免疫系統是機體抵御病原菌感染的第一道防線,通過特異識別、精確激活和高效應答清除病原菌的感染,保護機體健康。病原菌感染和宿主天然免疫防御是病原菌與宿主相互作用的重要體現,關鍵的科學問題是破解病原菌感染與免疫識別應答的分子機理。本課題組圍繞天然免疫防御和病原菌感染與耐藥這一主題開展了系統的研究工作,取得了重要的研究成果,包括破解宿主天然免疫應答中細胞焦亡的關鍵分子機制(Nature 2016,Cell 2020),揭示病原菌通過新穎的精氨酸糖基化修飾阻斷宿主死亡受體信號通路的完整分子機理(Mol Cell 2019),揭示超級細菌金屬β內酰胺酶NDM-1水解頭孢類抗生素的催化機制(JACS 2014)?,F階段課題組將繼續聚焦病原菌與宿主天然免疫通路的直接對話,深入研究病原菌效應蛋白拮抗宿主天然免疫防御通路的精確分子機制,揭示新型天然免疫受體識別病原相關分子模式激活免疫應答的工作原理,為抗菌感染、免疫調節和抗炎治療藥物的研發提供堅實的理論基礎。

          承擔項目情況:

           

          代表論著:

          1. Wang, K.#, Sun, Q.#, Zhong, X., Zeng, M., Zeng, H., Shi, X., Li, Z., Wang, Y., Zhao, Q., Shao, F.* & Ding, J.* (2020). Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 180, 941-55.

          2. Ding, J.*, Pan, X., Du, L., Yao, Q., Xue, J., Yao, H., Wang, D. C., Li, S.* & Shao, F.* (2019). Structural and functional insights into host death domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector. Mol Cell. 74, 922-35.

          3. Ding, J.* & Shao, F.* (2018). Growing a gasdermin pore in membranes of pyroptotic cells. EMBO J. 37, e100067.

          4. Ding, J. & Shao, F. (2017). SnapShot: The Noncanonical Inflammasome. Cell. 168, 544-4.

          5. Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D. C.* & Shao, F.* (2016). Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 535, 111-6.

          6. Wang, X., Hou, Y., Deng, K., Zhang, Y., Wang, D. C.* & Ding, J.* (2015). Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3. Structure. 23, 1087-96.

          7. Feng, H.#, Ding, J.#, Zhu, D.#, Liu, X., Xu, X., Zhang, Y., Zang, S., Wang, D. C.* & Liu, W.* (2014). Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins. J Am Chem Soc. 136, 14694-7.

          8. Wang, W.#, Ding, J.#, Zhang, Y., Hu, Y.* & Wang, D. C.* (2014). Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res. 42, 3478-91.

          9. Guo, L.#, Ding, J.#, Guo, R., Hou, Y., Wang, D. C.* & Huang, L.* (2014). Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea. J Biol Chem. 289, 1478-90.

          10. Xu, X., Wang, X., Zhang, Y., Wang, D. C.* & Ding, J.* (2013). Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III. Structure. 21, 1059-66.

          11. Wang, T.#, Ding, J.#, Zhang, Y., Wang, D. C.* & Liu, W.* (2013). Complex structure of type VI peptidoglycan muramidase effector and a cognate immunity protein. Acta Crystallogr D Biol Crystallogr. 69, 1889-900.

          12. Ding, J.#, Wang, W.#, Feng, H., Zhang, Y. & Wang, D. C. (2012). Structural insights into the Pseudomonas aeruginosa type VI virulence effector Tse1 bacteriolysis and self-protection mechanisms. J Biol Chem. 287, 26911-20.

          13. Gong, Y.#, Zhu, D.#, Ding, J.#, Dou, C. N., Ren, X., Gu, L., Jiang, T.* & Wang, D. C.*(2011). Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol. 18, 1297-9.

          14. Ding, J., Wang, X., Li, D. F., Hu, Y., Zhang, Y. & Wang, D. C. (2010). Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation. Biochem Biophys Res Commun. 399, 587-92.

          15. Ding, J., Bao, J., Zhu, D., Zhang, Y. & Wang, D. C. (2010). Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure. J Struct Biol. 171, 309-17.

           

          (資料來源:丁璟珒研究員,2020-12-28)

           

          公交上拨开少妇内裤挺进去

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