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        1. 當前位置 首頁 科研隊伍

          中科院青促會會員

          魏艷  博士 副研究員  

          中國科學院青年創新促進會會員
          中科院生物物理所,腦與認知科學國家重點實驗室

          研究方向:蛋白質異常修飾與代謝性疾病

          電子郵件:yanwei@ibp.ac.cn

          電       話:010-64888531

          通訊地址:北京市朝陽區大屯路15號(100101)

          英文版個人網頁:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.salesdujour.com/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582909.json

           

          簡       歷:

            2000.09 - 2005.06  北京大學護理學院,醫學學士

            2005.09 - 2010.06  中國科學院生物物理研究所,理學博士

            2010.07 - 2014.12  中國科學院生物物理研究所,助理研究員

            2014.07 - 2014.10  澳大利亞昆士蘭大學腦研究所,訪問學者

            2015.08 - 2016.08  澳大利亞昆士蘭大學腦研究所,國家公派訪問學者

            2015.01 - 至今       中國科學院生物物理研究所,副研究員

          獲獎及榮譽:

           

          社會任職:

           

          研究方向:

            從分子、細胞、動物水平研究蛋白質異常修飾(磷酸化、糖基化等)的促發因素、錯誤折疊以及與代謝性疾病的關系。

          承擔項目情況:

            1. 國家自然科學基金面上項目《核糖代謝異常在糖尿病腦病中的作用及機制研究》,2017-2020,直接經費60萬,負責人

            2. 國家青年科學基金項目《核糖糖基化導致Tau蛋白超磷酸化的分子機制研究》,2013-2015,23萬,負責人

          代表論著:

          1. Mou LX, Hu PD, Cao X, Chen Y, Xu Y, He T, Wei Y#, He RQ#. Comparison of bovine serum albumin glycation by ribose and fructose in vitro and in vivo. BBA Mol Basis Dis, 2022, 1868(1):166283. (#co-corresponding authors)

          2. Li T*, Wei Y*, Qu M, Mou L, Miao J, Xi M, Liu Y, He R. Formaldehyde and de/methylation in age-related cognitive impairment. Genes, 2021, 12(6): 913. (* co-first authors)

          3. Yu LX, Chen Y, Xu Y, He T, Wei Y#, He RQ#. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging (Albany NY), 2019, 11(14):4943-4969. (#co-corresponding authors)

          4. Wu BB, Wang YJ, Shi CG, Chen Y, Yu LX, Li J, Li WW, Wei Y#, He RQ#. Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction. J Alzheimers Dis, 2019, 71(1):291-305.

          5. Wu BB, Yu LX, Hu PD, Lu Y, Li J, Wei Y#, He RQ#. GRP78 protects CHO cells from ribosylation. BBA-Mol Cell Res, 2018, 1865:629-637. (#co-corresponding authors)

          6. Chen XX, Su T, Chen Y, He YG, Liu Y, Xu Y, Wei Y#, Li J, He RQ#. D-Ribose as a Contributor to Glycated Haemoglobin. Ebiomedicine, 2017, 25:143-153. (#co-corresponding authors)

          7. Hatch RJ, Wei Y, Xia D, Goetz J. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta Neuropathol, 2017, 133(5):717-730.

          8. Li T, Su T, He YG, Lu JH, Mo WC, Wei Y#, He RQ#. Brain formaldehyde is related to water intake behavior. Aging Dis, 2016, 10.14336/AD.2016.0323. ( #co-corresponding authors)

          9. Wei Y*, Wang YJ*, Wu BB, Zhang YH, He RQ. Ribosylated BSA monomer is severely toxic to SH-SY5Y cells. Prog Biochem Biophys, 2016, 43(6):579-591. (* co-first authors)

          10. Wu BB*, Wei Y*, Wang YJ, Su T, Zhou L, Liu Y, He RQ. Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget, 2015, 6(33):34128-42. (* co-first authors)

          11. Wei Y, Han CS, Wang YJ, Wu BB, Su T, Liu Y, He RQ. Ribosylation triggering Alzheimer’s disease-like Tau hyperphosphorylation via activation of CaMKII. Aging Cell, 2015, 14(5):754-763.

          12. Han CS, Lu Y, Wei Y#, Wu BB, Liu Y, He RQ#. D-Ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death Dis, 2014, 5, e1117. ( #co-corresponding authors)

          13. Lu Y, He HJ, Zhou J, Miao JY, Lu J, He YG, Pan R, Wei Y#, Liu Y, He RQ#. Hyperphosphorylation results in tau dysfunction in DNA folding and protection. J Alzheimers Dis, 2013, 37:551-563. ( #co-corresponding authors)

          14. Wei Y, Han CS, Zhou J, Liu Y, Chen L, He RQ. D-ribose in glycation and protein aggregation. Biochim Biophys Acta, 2012, 1820(4):488-494.

          15. Liu YY, Qiang M, Wei Y, He RQ. A novel molecular mechanism for nitrated alpha-synuclein-induced cell death. J Mol Cell Biol, 2011, 3:239–249.

          16. Chen L*, Wei Y*, Wang XQ, He RQ. Ribosylation rapidly induces a-synuclein to form highly cytotoxic molten globules of advanced glycation end products. PLoS ONE, 2010, 5(2):e9052. (* co-first authors)

          17. Wei Y*, Chen L*, Chen J, Ge L, He RQ. Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells. BMC Cell Biol, 2009, 10:10. (* co-first authors)

          18. Wei Y*, Qu MH*, Wang SX, Chen L, Wang DL, Liu Y, Hua Q, He RQ. Binding to the Minor Groove of the Double-Strand, Tau Protein Prevents DNA from Damage by Peroxidation. PLoS ONE, 2008, 3(7): e2600. (* co-first authors)

           

          (資料來源:魏艷副研究員,2021-11-02)

           

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