<address id="uqqsu"><pre id="uqqsu"><span id="uqqsu"></span></pre></address>

        <track id="uqqsu"></track>
        1. 當前位置 首頁 科研隊伍

          中科院青促會會員

          王彥英  博士 副研究員  

          國家"優秀青年基金"獲得者
          中國科學院青年創新促進會優秀會員

          研究方向:腫瘤干細胞和腫瘤發生

          電子郵件:wangyanying@ibp.ac.cn

          電       話:010-64884329

          通訊地址:北京市朝陽區大屯路15號(100101)

          英文版個人網頁:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.salesdujour.com/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582912.json

           

          簡       歷:

            1999.09 - 2002.07  山東大學生命科學學院

            2005.09 - 2008.07  北京農學院,獲碩士學位

            2008.08 - 2011.12  北京協和醫學院基礎醫學研究所,獲理學博士學位

            2012.01 - 2015.12  中國科學院生物物理研究所,助理研究員

            2016.01 - 至今       中國科學院生物物理研究所,副研究員

          獲獎及榮譽:

           

          社會任職:

           

          研究方向:

            腫瘤干細胞具有自我更新和分化的能力,是引起腫瘤耐藥、復發和轉移的重要原因。我們以肝癌為研究對象,探索其發病機制,研究肝癌干細胞的自我更新機制,并篩選發現新的肝癌干細胞標志物,為肝癌的個體化治療提供新的藥物靶點。

          承擔項目情況:

           

          代表論著:

          1. Wang Y#*, Wang J#, Li X#, Xiong X#, Wang J, Zhou Z, Zhu X, Yang G, Dominissini D, He L, Tian Y*, Yi C*, and Fan Z*. N1-methyladenosinemethylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021 Nov 2;12(1):6314.

          2. Gu Y#, Wang Y#*, He L#, Zhang J#, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y*, and Fan Z*. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Mol Cancer. 2021, 20(1):132.

          3. Wang Y#, He L#, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, and Fan Z. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015(16);413-425. (#equal contribution)

          4. Wang Y#, Zhu P#, Wang J#, Zhu X#, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y, and Fan Z. Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling. J Hepatol. 2018;69:861-872. (#equal contribution)

          5. Wang Y#, Zhu P#, Luo J#, Wang J#, Liu Z#, Wu W, Du Y, Ye B, Wang D, He L, Chen R, Tian Y, and Fan Z. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019 38(17):e101110. (#equal contribution)

          6. Wang Y#, Song G#, Qiu L, Qin X, Liu H, Li F, Wang X, Guo S, Zhang Y, and Li Z. Elevated Serum Levels of Circulating Immunoinflammation-Related Protein Complexes Are Associated with Cancer. J Proteome Res. 2014, 13(2): 710-719. (#equal contribution)

          7. Wang Y, Zhang Z, Shen H, Lu Y, Li H, Ren X, Wu G. TGF-β1/Smad7 signal pathway stimulates renal tubuloinsterstitial fibrosis induced by AAⅠ. J Recept Sig Transd Res. 2008, 28: 4, 413-428.

          8. Zhu P#, Wu J#, Wang Y#, Zhu X#, Lu T#, Liu B, He L, Ye B, Liu B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Y Du, li C, He L, Ren W, Wu X, Tian Y, and Fan Z. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Nat Cell Biol. 2018; 20: 1134-1144. (#equal contribution)

          9. Wu J#, Zhu P#, Lu T#, Du Y#, Wang Y#, He L, Ye B, Liu B, Yang L, Wang J, Gu Y, Lan J, Hao Y, He L, and Fan Z. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling. J Hepatol. 2019;70(5):918-929. (#equal contribution)

          10. Zhu P#, Wang Y#, Huang G, Ye B, Liu B, Wu J, Y Du, He L, and Fan Z. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016; 23 (7):631-639. (#equal contribution)

          11. Zhu P#, Wang Y#, Wu J, Huang G, Liu B, Ye B, Y Du, G Gao, Y Tian, He L, and Fan Z. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608. (#equal contribution)

          12. Zhu P#, Wang Y#, He L#, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, and Fan Z. Zic2 Drives Self-renewal of Human Liver Cancer Stem Cells. J Clin Invest. 2015;125(10):3795-3808. (#equal contribution)

          13. Zhu P#; Zhu X#; Wu J#; He L#; Lu T#; Wang Y; Liu B; Ye B; Sun L; Fan D; Wang J; Yang L; Qin X; Du Y; Li C; He L; Ren W; Wu X; Tian Y; Fan Z. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019, 20(2):183-+ DOI:10.1038/s41590-018-0297-6.

          14. Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X, and Fan Z. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signaling. Nat Commun. 2015;6:7122.

          15. Ye B#; Liu B#; Yang L#; Zhu X#; Zhang D#; Wu W; Zhu P; Wang Y; Wang S; Xia P; Du, Y; Meng S; Huang G; Wu J; Chen R; Tian Y; Fan Z. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO J. 2018, 37(8).

          16. Ye B#; Liu B#; Hao L#; Zhu X#; Yang L#; Wang S; Xia P; Du Y; Meng S; Huang G; Qin X; Wang Y; Yan X; Li C; Hao J; Zhu P; He L; Tian Y; Fan Z. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018, 9(1).

          17. Li C#; Du Y#; Yang Z#; He L; Wang Y; Hao L; Ding M; Yan R; Wang J; Fan Z*. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016, 76(5):1273-1283.

          18. Ye B#, Li C#, Yang Z#, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y, and Fan Z. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 211: 2439-2454.

          19. Yang X#, Xu M#, Wang Y, Xia P, Wang S, Ye B, Tong L, Jiang T, and Fan Z. Molecular mechanism for self-protection against type VI secretion system in Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2014, 70(4): 1094-1103.

          20. Song G, Liu Y, Wang Y, Ren G, Guo S, Ren J, Zhang L, and Li Z. Personalized biomarkers to monitor disease progression in advanced non-small-cell lung cancer patients treated with icotinib. Clinica Chimica Acta. 2015, 440:44-48.

          21. Chen G, Wang Y, Qin X, Li H, Guo Y, Wang Y, Liu H, Wang X, Song G, Li F, Guo S, Qiu L, and Li Z. Change in IgG1 Fc N-linked glycosylation in human lung cancer: age- and sex-related diagnostic potential. Electrophoresis. 2013, 34: 2407-2416.

          22. Chen G, Zhang L, Wang Y, Guo Y, Liu H, and Li Z. Letter to the editor. Probing gender-specific change in IgG1 Fc-galactosylation in non-small cell lung cancer patients treated with epidermal growth factor receptor inhibitor. Rapid Commun Mass Spectrom. 2013, 27, 1168-1172.

          23. Chen G, Wang Y, Qiu L, Qin X, Liu H, Wang X, Wang Y, Song G, Li F, Guo Y, Li F, Guo S, and Li Z. Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer. J Proteomic. 2012, 75(10), 2824-2834.

          24. Guo Y, Wang X, Qiu L, Qin X, Liu H, Wang Y, Li F, Chen G, Song G, Guo S, and Li Z. Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry. Clin Chim Acta. 2012, 414, 135-141.

          25. Li J, Zhang Z, Wang D, Wang Y, Li Y, and Wu G. TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Sig Transd Res. 2009, 29(5): 280-285.

           

          (資料來源:王彥英副研究員,2022-05-31)

           

          公交上拨开少妇内裤挺进去

                <address id="uqqsu"><pre id="uqqsu"><span id="uqqsu"></span></pre></address>

                <track id="uqqsu"></track>