<address id="uqqsu"><pre id="uqqsu"><span id="uqqsu"></span></pre></address>

        <track id="uqqsu"></track>
        1. 當前位置 首頁 科研隊伍

          中科院青促會會員

          柴謙  博士 副研究員  

          中國科學院青年創新促進會會員

          研究方向:免疫學及發育生物學

          電子郵件:qianchai@ibp.ac.cn

          電       話:010-64880046

          通訊地址:北京市朝陽區大屯路15號(100101)

          英文版個人網頁:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.salesdujour.com/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582913.json

           

          簡       歷:

            2003.08 - 2007.06  山東大學生命科學學院 理學學士

            2007.08 - 2009.06  瑞典烏普薩拉大學 理學碩士

            2009.11 - 2013.11  瑞士蘇黎世聯邦高等工業學院(ETH) 理學博士

            2013.12 - 2014.03  瑞士圣加倫州立醫院免疫生物學研究所 博士后

            2014.06 –至今       中國科學院生物物理研究所 副研究員

          獲獎及榮譽:

           

          社會任職:

           

          研究方向:

            主要從事免疫系統基質細胞微環境在淋巴器官和淋巴細胞發育與功能,以及在炎癥反應等免疫應答過程中的作用與機制的研究:

            1. 探索組織微環境對腸道天然淋巴細胞的發育、分化和功能的調控機制;

            2. 發掘穩態以及炎癥狀態下,組織微環境與淋巴細胞交互對話的作用機制;

            3. 探索慢性炎癥反應中,淋巴器官纖維化的發生機制;

            4. 探索基質細胞微環境在腫瘤轉移過程中的相關功能與機制。

          承擔項目情況:

            國家自然基金重大項目(81991493),2020-2024年

            國家自然基金面上項目(31970866),2020-2023年

            國家自然基金面上項目(81671537),2017-2020年

            國家重大科學研究計劃青年科學家項目計劃(973青年)(2015CB943400),2015-2019年

            國家自然基金青年基金(31400758),2015-2017年

          代表論著:

          1. Pian YY#, Chai Q#*, Ren BY, Wang Y, Lv MJ, Qiu J, Zhu MZ*. Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTβR Pathway during Listeria Infection. J Immunol. 2020 Aug 1, 205 (3) 853-863

          2. Wang WJ, Zhou XX, Bian YJ, Wang S, Chai Q, Guo ZQ, Wang ZN, Zhu P, Peng H, Yan XY, Li WB, Fu YX, Zhu MZ*. Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B. Nature Nanotechnology. 2020, 15, 406-416

          3. Wang Z, Wang W, Chai Q, Zhu M. Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LTβR Signaling. J Immunol. 2019 May 15; 202 (10):2999-3007.

          4. Wang ZN#, Chai Q#*, Zhu MZ*. Differential Roles of LTβR in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation. J Immunol. 2018 July 1; 201 (1):69-76.

          5. Chung J, Ebens CL, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest. 2017 Apr 3;127(4):1574-1588.

          6. Wu W, Shi Y, Xia H, Chai Q, Jin C, Ren B, Zhu M. Epithelial LTβR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice. Sci Rep. 2017 Mar 14;7:44481.

          7. Gil-Cruz C, Perez-Shibayama C, Onder L, Chai Q, Cupovic J, Cheng HW, Novkovic M, Lang P, Geuking M, McCoy K, Abe S, Cui GW, Ikuta K, Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol. 2016 Oct.

          8. Shi YY, Wu WW, Chai Q, Li QQ, Hou Y, Xia H, Ren BY, Xu HR, Guo XH, Jin CW, Lv MJ, Wang ZN, Fu YX& Zhu MZ. LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun. 2016 Aug.

          9. Onder L, Nindl V, Scandella E, Chai Q, Cheng HW, Caviezel-Firner S, Novkovic M, Bomze D, Maier R, Mair F, Ledermann B, Becher B, Waisman A, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction. Eur J Immunol. 2015 Aug; 45(8):2218-31.

          10. Fasnacht N, Huang HY, Koch U, Favre S, Auderset F, Chai Q, Onder L, Kallert S, Pinschewer DD, MacDonald HR, Tacchini-Cottier F, Ludewig B, Luther SA, Radtke F. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med. 2014 Oct 20; 211(11):2265-79.

          11. Perez-Shibayama C, Gil-Cruz C, Pastelin-Palacios R, Cervantes-Barragan L, Hisaki E, Chai Q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A, Lopez-Macias C, Ludewig B. IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi. J Immunol. 2014 Jun 1; 192(11):5192-200.

          12. Chai Q, Onder L, Scandella E, Gil-Cruz C, Perez-Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther SA, Thiel V, Rülicke T, Stein JV, Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity. 2013 May 23; 38(5):1013-24.

          13. Chai Q, Singh B, Peisker K, Metzendorf N, Ge X, Dasgupta S, Sanyal S. Organization of ribosomes and nucleoids in Escherichia coli cells during growth and in quiescence.J Biol Chem. 2014 Apr 18; 289(16):11342-52.

          14. Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, Stein J V, Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J Exp Med. 2013 Mar 11; 210(3):465-73.

          15. Onder L, Narang P, Scandella E, Chai Q, Iolyeva M, Hoorweg K, Halin C, Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood. 2012 Dec 6; 120(24):4675-83.

          16. Onder L, Scandella E, Chai Q, Firner S, Mayer C T, Sparwasser T, Thiel V, Rülicke T, Ludewig B. A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol. 2011; 2:50.

           

          (資料來源:柴謙副研究員,2020-12-28)

           

          公交上拨开少妇内裤挺进去

                <address id="uqqsu"><pre id="uqqsu"><span id="uqqsu"></span></pre></address>

                <track id="uqqsu"></track>