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        1. 當前位置 首頁 科研隊伍


          何玲莉  博士 副研究員  




          電       話:010-64888514




          簡       歷:

            2004.09 - 2008.06  中國農業大學,生物科學類,理學學士

            2008.09 - 2014.01  中國科學院大學,植物學,理學博士

            2014.04 - 2021.12  中國科學院生物物理研究所,生物大分子國家重點實驗室,助理研究員

            2022.01 - 至今        中國科學院生物物理研究所,生物大分子國家重點實驗室,副研究員






            1. 谷氨酸受體的結構和功能研究

            2. 電壓門控鈣離子通道的結構和功能研究

            3. 單分子熒光共振能量轉移技術




          1. Zhang, H.#, Su, J.#, Li, B.#, Gao, Y., Liu, M., He, L., Xu, H., Dong, Y., Zhang, X. C., & Zhao, Y.* (2022). Structure of human glycosylphosphatidylinositol transamidase. Nature structural & molecular biology, 29(3), 203-209. https://doi.org/10.1038/s41594-022-00726-6.

          2. He, L.#, Sun, J.#, Gao, Y.#, Li, B., Wang, Y., Dong, Y., An, W., Li, H., Yang, B., Ge, Y., Zhang, X. C.*, Shi, Y. S.*, & Zhao, Y.* (2021). Kainate receptor modulation by NETO2. Nature, 599(7884), 325-329. https://doi.org/10.1038/s41586-021-03936-y.

          3. Yang, W.#, Wang, Y.#, Guo, J.#, He, L., Zhou, Y., Zheng, H., Liu, Z., Zhu, P.*, & Zhang, X. C.* (2020). Cryo-electron microscopy structure of CLHM1 ion channel from Caenorhabditis elegans. Protein science: a publication of the Protein Society, 29(8), 1803-1815. https://doi.org/10.1002/pro.3904.

          4. Zhou, Y., Cao, C., He, L., Wang, X., & Zhang, X. C.* (2019). Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870. eLife, 8, e48822. https://doi.org/10.7554/eLife.48822.

          5. Wang, Y.#, Gao, H.#, He, L.#, Zhu, W., Yan, L., Chen, Q., & He, C.* (2019). The PHOSPHATE1 genes participate in salt and Pi signaling pathways and play adaptive roles during soybean evolution. BMC plant biology, 19(1), 353. https://doi.org/10.1186/s12870-019-1959-8.

          6. Zhu, Y., He, L., Liu, Y., Zhao, Y., & Zhang, X. C.* (2019). smFRET Probing Reveals Substrate-Dependent Conformational Dynamics of E. coli Multidrug MdfA. Biophysical journal, 116(12), 2296-2303. https://doi.org/10.1016/j.bpj.2019.04.034.

          7. Cao, C.#, Tan, Q.#, Xu, C., He, L., Yang, L., Zhou, Y., Zhou, Y., Qiao, A., Lu, M., Yi, C., Han, G. W., Wang, X., Li, X., Yang, H., Rao, Z., Jiang, H., Zhao, Y., Liu, J., Stevens, R. C., Zhao, Q., Zhang, X. C.*, Wu, B.* (2018). Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nature structural & molecular biology, 25(6), 488-495. https://doi.org/10.1038/s41594-018-0068-y.

          8. Zhang, H., Qiao, A., Yang, L., Van Eps, N., Frederiksen, K. S., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Cao, C., He, L., Yang, H., Lau, J., Ernst, O. P., Hanson, M. A., Stevens, R. C., Wang, M. W., Reedtz-Runge, S., Jiang, H., Zhao, Q.*, Wu, B.* (2018). Structure of the glucagon receptor in complex with a glucagon analogue. Nature, 553(7686), 106-110. https://doi.org/10.1038/nature25153.

          9. Zhao, M., Gu, Y., He, L., Chen, Q., & He, C.* (2015). Sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans. BMC plant biology, 15, 120. https://doi.org/10.1186/s12870-015-0519-0.

          10. Wang, L., He, L., Li, J., Zhao, J., Li, Z., & He, C.* (2014). Regulatory change at Physalis Organ Size 1 correlates to natural variation in tomatillo reproductive organ size. Nature communications, 5, 4271. https://doi.org/10.1038/ncomms5271.

          11. Zhao, M., He, L., Gu, Y., Wang, Y., Chen, Q., & He, C.* (2014). Genome-wide analyses of a plant-specific LIM-domain gene family implicate its evolutionary role in plant diversification. Genome biology and evolution, 6(4), 1000-1012. https://doi.org/10.1093/gbe/evu076.

          12. He, L., Zhao, M., Wang, Y., Gai, J., & He, C.* (2013). Phylogeny, structural evolution and functional diversification of the plant PHOSPHATE1 gene family: a focus on Glycine max. BMC evolutionary biology, 13, 103. https://doi.org/10.1186/1471-2148-13-103.





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