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        1. 當前位置 首頁 科研隊伍


          張紫豪  博士 高級工程師  




          電       話:010-64888462-123




          簡       歷:

            2007.09 – 2011.07  復旦大學,理學學士

            2011.09 – 2016.06  中國科學院大學,理學博士

            2016.07 – 2019.11  中國科學院生物物理研究所,助理研究員

            2019.12 – 至今        中國科學院生物物理研究所,高級工程師






            超高場(≥ 7 Tesla)磁共振成像(Magnetic Resonance Imaging, MRI)具有卓越的信噪比和對比度,可無創的獲得亞毫米尺度的醫學影像和功能影像,為腦疾病和腦科學的研究開辟了新的視野。我們基于7T MRI平臺開發多種模態的腦血管成像和腦功能成像技術,并探索其應用價值。


            1. 國家自然科學基金青年項目(82001804),基于7T超高場磁共振的同時多層采集和超分辨重建的顱內動脈粥樣硬化斑塊成像方法研究,2021-2023,主持。

            2. 北京市自然科學基金青年項目(7184226),基于局部激發的7T高分辨顱內穿支動脈管壁成像技術研發,2018-2019,主持。

            3. 科技部國家重點研發計劃(2017YFC1307904),癥狀性顱內外大動脈狹窄復發進展預測模型與干預策略研究,2017-2020,骨干。

            4. 國家自然科學基金中美合作與交流項目(81961128030),基于多模態影像學的CADASIL血腦屏障破壞機制研究,2020-2024,骨干。

            5. 北京市自然科學基金重點項目(7191003),基于神經網絡深度學習的腦卒中相關血管管壁斑塊量化分析及破裂風險預警模型研究,2020-2023,骨干。

            6. 北京市衛健委首都衛生發展科研專項(首發2020-2-5115),腦深部髓靜脈形態與腦小血管病認知障礙的相關性研究,2017-2023,骨干。

            7. 科技部國家重點研發計劃(2015CB351701),視覺認知的腦工作機理及高級腦機交互關鍵技術研究,2014-2019,參與。

            8. 國家自然科學基金面上項目(31871107),雙眼競爭中人腦視皮層亞層特異的7T超高場功能磁共振成像,2019-2022,參與。

            9. 國家自然科學基金面上項目(81871350),基于平衡式穩態自由進動的7T超高場高分辨率快速功能磁共振成像方法研究,2019-2022,參與。

            10. 國家自然科學基金面上項目(81870833),基于多模態影像融合技術的頸動脈狹窄患者腦網絡與認知功能研究,2019-2022,參與。


          1. Sun, C. and Wu, Y., Ling, C., Xie, Z., Sun, Y., Xie, Z., Li, Z., Fang, X., Kong, Q., An, J., Wang, B., Zhuo Y., Zhang W., Wang Z., Yuan Y.# and Zhang, Z.#, 2021. Reduced Blood Flow Velocity in Lenticulostriate Arteries of Patients with CADASIL Assessed by PC-MRA at 7T. Journal of Neurology, Neurosurgery and Psychiatry, 93(4), pp.451-452. http://dx.doi.org/10.1136/jnnp-2021-326258

          2. Kong, Q., Wu, Y., Weng, D., An, J., Zhuo, Y.# and Zhang, Z.#, 2021. Optimized Inner-Volume 3D TSE for High-Resolution Vessel Wall Imaging of Intracranial Perforating Arteries at 7T. Frontiers in Neuroscience, 15, p.66. https://doi.org/10.3389/fnins.2021.620172

          3. Sun, C. and Wu, Y., Ling, C., Xie, Z., Kong, Q., Fang, X., An, J., Sun, Y., Zhang, W., Yang, Q., Wang, Z., Zhang, Z.# and Yuan, Y.#, 2020. Deep Gray Matter Iron Deposition and Its Relationship to Clinical Features in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients: A 7.0-T Magnetic Resonance Imaging Study. Stroke, 51(6), 1750-1757. https://doi.org/10.1161/STROKEAHA.119.028812

          4. Zhang, Z. and Fan, Z., Kong, Q., Xiao, J., Wu, F., An, J., Yang, Q.#, Li, D. and Zhuo, Y., 2019. Visualization of the lenticulostriate arteries at 3T using black-blood T1-weighted intracranial vessel wall imaging: comparison with 7T TOF-MRA. European radiology, 29(3), pp.1452-1459. https://doi.org/10.1007/s00330-018-5701-y

          5. Ling, C. and Zhang, Z., Wu, Y., Fang, X., Kong, Q., Zhang, W., Wang, Z., Yang, Q.# and Yuan, Y.#, 2019. Reduced Venous Oxygen Saturation Associates With Increased Dependence of Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: A 7.0-T Magnetic Resonance Imaging Study. Stroke, 50(11), pp.3128-3134. https://doi.org/10.1161/STROKEAHA.119.026376

          6. Huang, L., Zuo, Z., Bai, J., Zong, R., Zhou, J., Cui, Z., Wang, J, Chai, X., Wang, Z., An, J., Zhuo Y., Boada, F., Yu, X., Ling, Z., Qu, B., Pan, L.# and Zhang, Z., 2021. Sodium MRI at 7T for Early Response Evaluation of Intracranial Tumors following Stereotactic Radiotherapy Using the CyberKnife. American Journal of Neuroradiology, 43(2), pp.181-187. https://doi.org/10.3174/ajnr.A7404

          7. Feng, J., Liu, X., Zhang, Z.#, Wu, Y., Li, Z., Zhang, Q., Jiang, Y., You, W., Liu, P., Wang, Y., Mossa-Basha, M., Saloner, D., Li, Y#. and Zhu, C., 2021. Comparison of 7T and 3T vessel wall MRI for the evaluation of intracranial aneurysm wall. European Radiology, pp.1-9. https://doi.org/10.1007/s00330-021-08331-9

          8. Wei, N., Zhang, X., An, J., Zhuo, Y. and Zhang, Z.#, 2021. A processing pipeline for quantifying lenticulostriate artery vascular volume in subcortical nuclei. Frontiers in Neurology, p.1320. https://doi.org/10.3389/fneur.2021.700476

          9. Liu, X., Feng, J., Li, Z., Zhang, Z.#, Zhang, Q., Jiang, Y., Huo, X., Chai, X., Wu, Y., Kong, Q., Liu, P., Ge, H., Jin, H., An, J., Jiang, P., Saloner, D., Li, Y.# and Zhu, C. 2021. Quantitative analysis of unruptured intracranial aneurysm wall thickness and enhancement using 7T high resolution, black blood magnetic resonance imaging. Journal of NeuroInterventional Surgery. http://doi.org/10.1136/neurintsurg-2021-017688

          10. Wang, P., Cai, H., Luo, R., Zhang, Z., Zhang, D. and Zhang, Y.#, 2021. Measurement of Cortical Atrophy and Its Correlation to Memory Impairment in Patients With Asymptomatic Carotid Artery Stenosis Based on VBM-DARTEL. Frontiers in Aging Neuroscience, p.304. https://doi.org/10.3389/fnagi.2021.620763

          11. Sun, K., Cui, J., Xue, R., Jiang, T., Wang, B., Zhang, Z., Zhuo, Y., Zhou, X.J., Liang, S., Yu, X. and Chen, L., 2021. New imaging features of tuberous sclerosis complex: A 7 T MRI study. NMR in Biomedicine, 34(9), p.e4565. https://doi.org/10.1002/nbm.4565

          12. Liu, X., Zhang, Z., Zhu, C., Feng, J., Liu, P., Kong, Q., Zhang, X., Zhang, Q., Jin, H., Ge, H., Jiang, Y., Saloner, D. and Li, Y.#, 2020. Wall enhancement of intracranial saccular and fusiform aneurysms may differ in intensity and extension: a pilot study using 7-T high-resolution black-blood MRI. European Radiology, pp.1-7. https://doi.org/10.1007/s00330-019-06275-9

          13. Qian, Y., Zou, J., Zhang, Z., An, J., Zuo, Z., Zhuo, Y., Wang, D.J. and Zhang, P., 2020. Robust functional mapping of layer-selective responses in human lateral geniculate nucleus with high-resolution 7T fMRI. Proceedings of the Royal Society B, 287(1925), p.20200245. https://doi.org/10.1098/rspb.2020.0245

          14. Liu, C., Guo, F., Qian, C., Zhang, Z., Sun, K., Wang, D.J., He, S. and Zhang, P., 2020. Layer-dependent multiplicative effects of spatial attention on contrast responses in human early visual cortex. Progress in Neurobiology, p.101897. https://doi.org/10.1016/j.pneurobio.2020.101897

          15. Kong, Q. and Zhang, Z.#, Yang, Q., Fan, Z., Wang, B., An, J. and Zhuo, Y.#, 2019. 7T TOF-MRA Shows Modulated Orifices of Lenticulostriate Arteries Associated with Atherosclerotic Plaques in Patients with Lacunar Infarcts. European Journal of Radiology, 118, pp.271-276. https://doi.org/10.1016/j.ejrad.2019.07.032

          16. Ling, C. and Fang, X., Kong, Q., Sun, Y., Wang, B., Zhuo, Y., An, J., Zhang, W., Wang, Z., Zhang, Z.# and Yuan, Y.#, 2019. Lenticulostriate Arteries and Basal Ganglia Changes in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, A High-Field MRI study. Frontiers in Neurology, 10, p.870. https://doi.org/10.3389/fneur.2019.00870

          17. Wei, N., Zhang, Z.#, An, J., Weng, D. and Zhuo, Y., 2018. Improved visualization of superficial temporal artery using segmented time-of-flight MR angiography with venous suppression at 7T. Neuroradiology, 60(11), pp.1243-1246. https://doi.org/10.1007/s00234-018-2099-9

          18. Cong, F., Wang, J.W., Wang, B., Yang, Z., An, J., Zuo, Z., Zhang, Z., Zhang, Y.Q.# and Zhuo, Y.#, 2018. Direct localisation of the human pedunculopontine nucleus using MRI: a coordinate and fibre-tracking study. European radiology, 28(9), pp.3882-3892. https://doi.org/10.1007/s00330-017-5299-5

          19. Zhang, Z., Deng, X., Weng, D., An, J., Zuo, Z., Wang, B., Wei, N., Zhao, J. and Xue, R.#, 2015. Segmented TOF at 7 T MRI: technique and clinical applications. Magnetic resonance imaging, 33(9), pp.1043-1050. https://doi.org/10.1016/j.mri.2015.07.002

          20. Deng, X., Zhang, Z., Zhang, Y., Zhang, D., Wang, R., Ye, X., Xu, L., Wang, B., Wang, K. and Zhao, J.#, 2016. Comparison of 7.0-and 3.0-T MRI and MRA in ischemic-type moyamoya disease: preliminary experience. Journal of neurosurgery, 124(6), pp.1716-1725. https://doi.org/10.3171/2015.5.JNS15767

          21. Fang, X.J., Yu, M., Wu, Y., Zhang, Z.H., Wang, W.W., Wang, Z.X. and Yuan, Y.#, 2017. Study of enhanced depth imaging optical coherence tomography in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Chinese medical journal, 130(9), p.1042. https://doi.org/10.4103/0366-6999.204935

          22. Ma, Y.J., Liu, W., Zhao, X., Tang, W., Zhang, Z., Tang, X., Fan, Y., Li, H. and Gao, J.H.#, 2015. Improved adaptive reconstruction of multichannel MR images. Medical physics, 42(2), pp.637-644. https://doi.org/10.1118/1.4905163





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