<address id="uqqsu"><pre id="uqqsu"><span id="uqqsu"></span></pre></address>

        <track id="uqqsu"></track>
        1. 當前位置:  首頁 >> 最新重要論文

          最新重要論文

          ATF4-dependent fructolysis fuels growth of glioblastoma multiforme, Nat Commun, 16 Oct 2022

          發布時間:2022年10月16日

          Nature Communications, 16 October, 2022, DOI:https://doi.org/10.1038/s41467-022-33859-9

          ATF4-dependent fructolysis fuels growth of glioblastoma multiforme

          Chao Chen, Zhenxing Zhang, Caiyun Liu, Bin Wang, Ping Liu, Shu Fang, Fan Yang, Yongping You & Xinjian Li 

          Abstract

          Excessive consumption of fructose in the Western diet contributes to cancer development. However, it is still unclear how cancer cells coordinate glucose and fructose metabolism during tumor malignant progression. We demonstrate here that glioblastoma multiforme (GBM) cells switch their energy supply from glycolysis to fructolysis in response to glucose deprivation. Mechanistically, glucose deprivation induces expression of two essential fructolytic proteins GLUT5 and ALDOB through selectively activating translation of activating transcription factor 4 (ATF4). Functionally, genetic or pharmacological disruption of ATF4-dependent fructolysis significantly inhibits growth and colony formation of GBM cells in vitro and GBM growth in vivo. In addition, ATF4, GLUT5, and ALDOB levels positively correlate with each other in GBM specimens and are poor prognostic indicators in GBM patients. This work highlights ATF4-dependent fructolysis as a metabolic feature and a potential therapeutic target for GBM.

          文章鏈接:https://www.nature.com/articles/s41467-022-33859-9

          相關報道:http://www.salesdujour.com/kyjz/zxdt/202210/t20221017_6532805.html

           

           

              附件下載:
          公交上拨开少妇内裤挺进去

                <address id="uqqsu"><pre id="uqqsu"><span id="uqqsu"></span></pre></address>

                <track id="uqqsu"></track>